Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma

Anna Migliazza; Stefano Martinotti; Weiyi Chen; Carlo Fusco; Bihui Ye; Daniel M. Knowles; Kenneth Offit; R. S.K. Chaganti; Riccardo Dalla-Favera

doi:10.1073/pnas.92.26.12520

Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma

Anna Migliazza, Stefano Martinotti, Weiyi Chen, Carlo Fusco, Bihui Ye, Daniel M. Knowles, Kenneth Offit, R. S.K. Chaganti, Riccardo Dalla-Favera

Research output: Contribution to journal › Article › peer-review

328 Scopus citations

Abstract

The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10^-3-1.6 × 10^-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.

Original language	English (US)
Pages (from-to)	12520-12524
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	92
Issue number	26
DOIs	https://doi.org/10.1073/pnas.92.26.12520
State	Published - Dec 19 1995
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.92.26.12520

Cite this

Migliazza, A., Martinotti, S., Chen, W., Fusco, C., Ye, B., Knowles, D. M., Offit, K., Chaganti, R. S. K., & Dalla-Favera, R. (1995). Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America, 92(26), 12520-12524. https://doi.org/10.1073/pnas.92.26.12520

Migliazza, A, Martinotti, S, Chen, W, Fusco, C, Ye, B, Knowles, DM, Offit, K, Chaganti, RSK & Dalla-Favera, R 1995, 'Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 26, pp. 12520-12524. https://doi.org/10.1073/pnas.92.26.12520

@article{461e221c43d446f4a5876e8e5e898abf,

title = "Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma",

abstract = "The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10-3-1.6 × 10-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.",

author = "Anna Migliazza and Stefano Martinotti and Weiyi Chen and Carlo Fusco and Bihui Ye and Knowles, {Daniel M.} and Kenneth Offit and Chaganti, {R. S.K.} and Riccardo Dalla-Favera",

year = "1995",

month = dec,

day = "19",

doi = "10.1073/pnas.92.26.12520",

language = "English (US)",

volume = "92",

pages = "12520--12524",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "26",

}

TY - JOUR

T1 - Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma

AU - Migliazza, Anna

AU - Martinotti, Stefano

AU - Chen, Weiyi

AU - Fusco, Carlo

AU - Ye, Bihui

AU - Knowles, Daniel M.

AU - Offit, Kenneth

AU - Chaganti, R. S.K.

AU - Dalla-Favera, Riccardo

PY - 1995/12/19

Y1 - 1995/12/19

N2 - The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10-3-1.6 × 10-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.

AB - The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10-3-1.6 × 10-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.

UR - http://www.scopus.com/inward/record.url?scp=0029614378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029614378&partnerID=8YFLogxK

U2 - 10.1073/pnas.92.26.12520

DO - 10.1073/pnas.92.26.12520

M3 - Article

C2 - 8618933

AN - SCOPUS:0029614378

SN - 0027-8424

VL - 92

SP - 12520

EP - 12524

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 26

ER -

Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this