Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis

Gromoslaw A. Smolen; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Woo J. Kim; Miguel N. Rivera; Sara M. Haserlat; Ross A. Okimoto; Eunice Kwak; Sonika Dahiya; Judy E. Garber; Daphne W. Bell; Dennis C. Sgroi; Lynda Chin; Chu Xia Deng; Daniel A. Haber

doi:10.1158/0008-5472.CAN-05-4181

Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis

Gromoslaw A. Smolen, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Woo J. Kim, Miguel N. Rivera, Sara M. Haserlat, Ross A. Okimoto, Eunice Kwak, Sonika Dahiya, Judy E. Garber, Daphne W. Bell, Dennis C. Sgroi, Lynda Chin, Chu Xia Deng, Daniel A. Haber

Research output: Contribution to journal › Article › peer-review

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Abstract

In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driven by loss of Brca1 and Trp53. Whereas analogous MET amplification was not found in human breast cancers, the identification of a dominant somatic genetic lesion in the Brca1/Trp53 mouse model suggests that recurrent secondary hits may also exist in BRCA1-initiated human breast cancer.

Original language	English (US)
Pages (from-to)	3452-3455
Number of pages	4
Journal	Cancer research
Volume	66
Issue number	7
DOIs	https://doi.org/10.1158/0008-5472.CAN-05-4181
State	Published - Apr 1 2006
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/0008-5472.CAN-05-4181

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Smolen, G. A., Muir, B., Mohapatra, G., Barmettler, A., Kim, W. J., Rivera, M. N., Haserlat, S. M., Okimoto, R. A., Kwak, E., Dahiya, S., Garber, J. E., Bell, D. W., Sgroi, D. C., Chin, L., Deng, C. X., & Haber, D. A. (2006). Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer research, 66(7), 3452-3455. https://doi.org/10.1158/0008-5472.CAN-05-4181

Smolen, GA, Muir, B, Mohapatra, G, Barmettler, A, Kim, WJ, Rivera, MN, Haserlat, SM, Okimoto, RA, Kwak, E, Dahiya, S, Garber, JE, Bell, DW, Sgroi, DC, Chin, L, Deng, CX & Haber, DA 2006, 'Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis', Cancer research, vol. 66, no. 7, pp. 3452-3455. https://doi.org/10.1158/0008-5472.CAN-05-4181

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title = "Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis",

abstract = "In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driven by loss of Brca1 and Trp53. Whereas analogous MET amplification was not found in human breast cancers, the identification of a dominant somatic genetic lesion in the Brca1/Trp53 mouse model suggests that recurrent secondary hits may also exist in BRCA1-initiated human breast cancer.",

author = "Smolen, {Gromoslaw A.} and Beth Muir and Gayatry Mohapatra and Anne Barmettler and Kim, {Woo J.} and Rivera, {Miguel N.} and Haserlat, {Sara M.} and Okimoto, {Ross A.} and Eunice Kwak and Sonika Dahiya and Garber, {Judy E.} and Bell, {Daphne W.} and Sgroi, {Dennis C.} and Lynda Chin and Deng, {Chu Xia} and Haber, {Daniel A.}",

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AU - Muir, Beth

AU - Mohapatra, Gayatry

AU - Barmettler, Anne

AU - Kim, Woo J.

AU - Rivera, Miguel N.

AU - Haserlat, Sara M.

AU - Okimoto, Ross A.

AU - Kwak, Eunice

AU - Dahiya, Sonika

AU - Garber, Judy E.

AU - Bell, Daphne W.

AU - Sgroi, Dennis C.

AU - Chin, Lynda

AU - Deng, Chu Xia

AU - Haber, Daniel A.

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AB - In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driven by loss of Brca1 and Trp53. Whereas analogous MET amplification was not found in human breast cancers, the identification of a dominant somatic genetic lesion in the Brca1/Trp53 mouse model suggests that recurrent secondary hits may also exist in BRCA1-initiated human breast cancer.

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Frequent Met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis

Abstract

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