TY - JOUR
T1 - Frailty Resilience Score
T2 - A Novel Measure of Frailty Resilience Associated With Protection From Frailty and Survival
AU - Milman, Sofiya
AU - Lerman, Ben
AU - Ayers, Emmeline
AU - Zhang, Zhengdong
AU - Sathyan, Sanish
AU - Levine, Morgan
AU - Ye, Kenny
AU - Gao, Tina
AU - Higgins-Chen, Albert
AU - Barzilai, Nir
AU - Verghese, Joe
N1 - Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2023/10/9
Y1 - 2023/10/9
N2 - Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect against frailty. First, a reliable quantification of frailty resilience is needed. We developed a novel measure of frailty resilience, the Frailty Resilience Score (FRS), that integrates frailty genetic risk, age, and sex. Application of FRS to the LonGenity cohort (n = 467, mean age 74.4) demonstrated its validity compared to phenotypic frailty and its utility as a reliable predictor of overall survival. In a multivariable-adjusted analysis, 1-standard deviation increase in FRS predicted a 38% reduction in the hazard of mortality, independent of baseline frailty (p < .001). Additionally, FRS was used to identify a proteomic profile of frailty resilience. FRS was shown to be a reliable measure of frailty resilience that can be applied to biological studies of resilience.
AB - Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect against frailty. First, a reliable quantification of frailty resilience is needed. We developed a novel measure of frailty resilience, the Frailty Resilience Score (FRS), that integrates frailty genetic risk, age, and sex. Application of FRS to the LonGenity cohort (n = 467, mean age 74.4) demonstrated its validity compared to phenotypic frailty and its utility as a reliable predictor of overall survival. In a multivariable-adjusted analysis, 1-standard deviation increase in FRS predicted a 38% reduction in the hazard of mortality, independent of baseline frailty (p < .001). Additionally, FRS was used to identify a proteomic profile of frailty resilience. FRS was shown to be a reliable measure of frailty resilience that can be applied to biological studies of resilience.
KW - FRS
KW - Genetics
KW - Longevity
KW - Proteomics
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U2 - 10.1093/gerona/glad138
DO - 10.1093/gerona/glad138
M3 - Article
C2 - 37246648
AN - SCOPUS:85173583959
SN - 1079-5006
VL - 78
SP - 1771
EP - 1777
JO - The journals of gerontology. Series A, Biological sciences and medical sciences
JF - The journals of gerontology. Series A, Biological sciences and medical sciences
IS - 10
ER -