TY - JOUR
T1 - Fragmin in unstable angina pectoris or in non-Q-wave acute myocardial infarction (the FRIC study)
AU - Klein, Werner
AU - Buchwald, Arnd
AU - Hillis, W. Stewart
AU - Monrad, Scott
AU - Sanz, Ginés
AU - Turpie, Alexander G.G.
AU - Van Der Meer, Jan
AU - Olaisson, Eric
AU - Undeland, Sven
AU - Ludwig, Karin
N1 - Funding Information:
The authors thank the many doctors, nurses, and monitoring personnel who made this study possible, and especially the patients for their participation. The study was supported by Pharmacia & Upjohn, Stockholm, Sweden.
PY - 1997/9/4
Y1 - 1997/9/4
N2 - The safety and efficacy of weight-adjusted, low-molecular-weight heparin (dalteparin) was compared with that of unfractionated heparin during 6 days of treatment in 1,482 patients with unstable angina or non-Q-wave myocardial infarction. Dalteparin, at a lower dose, was compared with placebo during the following 39 days. No significant outcome difference was found between the 2 treatment regimens in the unblinded phase (days 1-6). Between days 6-45 the rates of death, myocardial infarction, and recurrence of angina were comparable between the active treatment and placebo groups. The results suggest that twice-daily administration of subcutaneous dalteparin may be an effective and safe alternative to unfractionated heparin during the acute phase of unstable coronary artery disease. Prolonged treatment with dalteparin at a lower once daily dose did not confer any additional benefit over aspirin (75-165 mg) alone.
AB - The safety and efficacy of weight-adjusted, low-molecular-weight heparin (dalteparin) was compared with that of unfractionated heparin during 6 days of treatment in 1,482 patients with unstable angina or non-Q-wave myocardial infarction. Dalteparin, at a lower dose, was compared with placebo during the following 39 days. No significant outcome difference was found between the 2 treatment regimens in the unblinded phase (days 1-6). Between days 6-45 the rates of death, myocardial infarction, and recurrence of angina were comparable between the active treatment and placebo groups. The results suggest that twice-daily administration of subcutaneous dalteparin may be an effective and safe alternative to unfractionated heparin during the acute phase of unstable coronary artery disease. Prolonged treatment with dalteparin at a lower once daily dose did not confer any additional benefit over aspirin (75-165 mg) alone.
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U2 - 10.1016/S0002-9149(97)00487-6
DO - 10.1016/S0002-9149(97)00487-6
M3 - Article
C2 - 9296467
AN - SCOPUS:0030798740
SN - 0002-9149
VL - 80
SP - 30E-34E
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 5 A
ER -