Fortuitous detection of endocervical adenocarcinoma in situ: A report of 2 cases

Elizabeth P. Gurney, Stephanie V. Blank

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


BACKGROUND: The Pap smear and oncogenic human papillomavirus (HPV) testing are highly effective in screening for cervical cancer precursors. Cervical glandular abnormalities, however, are more difficult to detect and monitor than are squamous lesions. CASES: We present 2 cases of premenopausal women with normal Pap smears, but oncogenic HPV infection and metrorrhagia. Biopsies revealed adenocarcinoma in situ, and cold-knife conization was performed. CONCLUSION: Because glandular cancerous precursors can remain undetected by Pap screening, thorough evaluation of symptomatic patients with high-risk HPV is imperative.

Original languageEnglish (US)
Pages (from-to)451-453
Number of pages3
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number7
StatePublished - Jul 2009
Externally publishedYes


  • Adenocarcinoma in situ
  • Human papillomavirus
  • Papanicolaou test
  • Uterine cervix

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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