TY - JOUR
T1 - Female reproductive tract microbiome and early miscarriages
AU - Lebedeva, Olga P.
AU - Popov, Vasily N.
AU - Syromyatnikov, Mikhail Y.
AU - Starkova, Natalia N.
AU - Maslov, Alexander Y.
AU - Kozarenko, Olesya N.
AU - Gryaznova, Mariya V.
N1 - Publisher Copyright:
© 2022 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
PY - 2023/2
Y1 - 2023/2
N2 - Miscarriage is one of the main causes of reproductive loss, which can lead to a number of physical and psychological complications and other long-term consequences. However, the role of vaginal and uterine microbiome in such complications is poorly understood. To review the published data on the function of the female reproductive tract microbiome in the pathogenesis of early miscarriages. The articles published over the past 20 years and deposited in PubMed, Google Academy, Scopus, Elibrary, ResearchGate, and EBSCO databases were analyzed. The review presents new data on the impact of the vaginal and uterine microbiome on the local immunity, including defense against sexually transmitted infections, and its association with other factors of miscarriages. The studies on the microbiome of non-pregnant women with recurrent miscarriages in the anamnesis, patients undergoing IVF, and pregnant women with miscarriages, as well as new directions in the microbiome research are discussed. The majority of studies have demonstrated that the dominant species of the vaginal and uterine microbiome in patients with early miscarriages are non-Lactobacillus bacteria. As many of these bacteria have not previously been detected by cultural studies and their role in obstetric complications is not well defined, further research on the female reproductive tract microbiome, including the microbiome of the cervix uteri, is needed to develop new approaches for the prognosis and prevention of miscarriages.
AB - Miscarriage is one of the main causes of reproductive loss, which can lead to a number of physical and psychological complications and other long-term consequences. However, the role of vaginal and uterine microbiome in such complications is poorly understood. To review the published data on the function of the female reproductive tract microbiome in the pathogenesis of early miscarriages. The articles published over the past 20 years and deposited in PubMed, Google Academy, Scopus, Elibrary, ResearchGate, and EBSCO databases were analyzed. The review presents new data on the impact of the vaginal and uterine microbiome on the local immunity, including defense against sexually transmitted infections, and its association with other factors of miscarriages. The studies on the microbiome of non-pregnant women with recurrent miscarriages in the anamnesis, patients undergoing IVF, and pregnant women with miscarriages, as well as new directions in the microbiome research are discussed. The majority of studies have demonstrated that the dominant species of the vaginal and uterine microbiome in patients with early miscarriages are non-Lactobacillus bacteria. As many of these bacteria have not previously been detected by cultural studies and their role in obstetric complications is not well defined, further research on the female reproductive tract microbiome, including the microbiome of the cervix uteri, is needed to develop new approaches for the prognosis and prevention of miscarriages.
KW - Atopobium
KW - Bifidobacterium
KW - Gardnerella
KW - Lactobacillus
KW - Megasphaera
KW - Vaginal microbiome
KW - anembryonic pregnancy
KW - early miscarriage
KW - early pregnancy loss
KW - local immunity
KW - missed abortion
KW - sexually transmitted diseases
KW - spontaneous abortion
KW - uterine microbiome
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U2 - 10.1111/apm.13288
DO - 10.1111/apm.13288
M3 - Review article
C2 - 36511842
AN - SCOPUS:85145396435
SN - 0903-4641
VL - 131
SP - 61
EP - 76
JO - APMIS
JF - APMIS
IS - 2
ER -