Abstract
Functionalized arylmagnesium reagents bearing an ester, cyano, nonaflate or trialkylsilyloxy group undergo fast cross-coupling reactions with alkenyl iodides or bromides in the presence of catalytic amounts of Fe(acac)3 (5 mol%) at-20 °C within 1 hour resulting in the formation of the desired cross-coupling products in satisfactory yields. Excellent yields can be achieved by performing the cross-coupling reaction on solid phase by generating the Grignard reagent on the resin.
Original language | English (US) |
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Pages (from-to) | 1901-1904 |
Number of pages | 4 |
Journal | Synlett |
Issue number | 12 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Cross-coupling reaction
- Iodine-magnesium exchange
- Iron(III)-catalysis
- Magnesium
ASJC Scopus subject areas
- Organic Chemistry