Fast reductive ligation of S-nitrosothiols

Hua Wang; Ming Xian

doi:10.1002/anie.200801654

Fast reductive ligation of S-nitrosothiols

Hua Wang, Ming Xian

Biochemistry

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

(Chemical Equation Presented) "Nitroso" knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.

Original language	English (US)
Pages (from-to)	6598-6601
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	35
DOIs	https://doi.org/10.1002/anie.200801654
State	Published - Aug 18 2008

Keywords

Nitrenes
Nitrogen oxides
Reductive ligation
S-nitrosothiols

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200801654

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keywords = "Nitrenes, Nitrogen oxides, Reductive ligation, S-nitrosothiols",

author = "Hua Wang and Ming Xian",

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AU - Xian, Ming

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AB - (Chemical Equation Presented) "Nitroso" knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.

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KW - Nitrogen oxides

KW - Reductive ligation

KW - S-nitrosothiols

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Fast reductive ligation of S-nitrosothiols

Abstract

Keywords

ASJC Scopus subject areas

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