Fast reductive ligation of S-nitrosothiols

Hua Wang, Ming Xian

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


(Chemical Equation Presented) "Nitroso" knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.

Original languageEnglish (US)
Pages (from-to)6598-6601
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number35
StatePublished - Aug 18 2008


  • Nitrenes
  • Nitrogen oxides
  • Reductive ligation
  • S-nitrosothiols

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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