TY - JOUR
T1 - Familial erythroleukemia
T2 - A distinct clinical and genetic type of familial leukemias
AU - Novik, Yelena
AU - Marino, Patricia
AU - Makower, Della F.
AU - Wiernik, Peter H.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - A family with erythroleukemia is presented, in which father and son were diagnosed at the same age, but 20 years apart, with almost identical clinical and morphological features of the disease. No environmental factors were identified. The karyotypic abnormalities of the bone marrow blasts in the son demonstrated 2 major clones, involving chromosomes 5 and 7, as well as 8, 13, 16 and 21. Both patients demonstrated a poor response to chemotherapy. Previously described families with erythroleukemia are reviewed with available specific karyotypic aberrations.
AB - A family with erythroleukemia is presented, in which father and son were diagnosed at the same age, but 20 years apart, with almost identical clinical and morphological features of the disease. No environmental factors were identified. The karyotypic abnormalities of the bone marrow blasts in the son demonstrated 2 major clones, involving chromosomes 5 and 7, as well as 8, 13, 16 and 21. Both patients demonstrated a poor response to chemotherapy. Previously described families with erythroleukemia are reviewed with available specific karyotypic aberrations.
KW - Acute myelogenous leukemia
KW - Erythroleukemia
KW - Genetic predisposition
KW - Karyotype
UR - http://www.scopus.com/inward/record.url?scp=0031820558&partnerID=8YFLogxK
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U2 - 10.3109/10428199809057551
DO - 10.3109/10428199809057551
M3 - Article
C2 - 9713970
AN - SCOPUS:0031820558
SN - 1042-8194
VL - 30
SP - 395
EP - 401
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 3-4
ER -
