Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study

Barbara Putman; Lies Lahousse; David G. Goldfarb; Rachel Zeig-Owens; Theresa Schwartz; Ankura Singh; Brandon Vaeth; Charles B. Hall; Elizabeth A. Lancet; Mayris P. Webber; Hillel W. Cohen; David J. Prezant; Michael D. Weiden

doi:10.3390/ijerph17239056

Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study

Barbara Putman, Lies Lahousse, David G. Goldfarb, Rachel Zeig-Owens, Theresa Schwartz, Ankura Singh, Brandon Vaeth, Charles B. Hall, Elizabeth A. Lancet, Mayris P. Webber, Hillel W. Cohen, David J. Prezant, Michael D. Weiden

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The factors that predict treatment of lung injury in occupational cohorts are poorly defined. We aimed to identify patient characteristics associated with initiation of treatment with inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) >2 years among World Trade Center (WTC)-exposed firefighters. The study population included 8530 WTC-exposed firefighters. Multivariable logistic regression assessed the association of patient characteristics with ICS/LABA treatment for >2 years over two-year intervals from 11 September 2001–10 September 2017. Cox proportional hazards models measured the association of high probability of ICS/LABA initiation with actual ICS/LABA initiation in subsequent intervals. Between 11 September 2001–1 July 2018, 1629/8530 (19.1%) firefighters initiated ICS/LABA treatment for >2 years. Forced Expiratory Volume in 1 s (FEV₁), wheeze, and dyspnea were consistently and independently associated with ICS/LABA treatment. High-intensity WTC exposure was associated with ICS/LABA between 11 September 2001– 10 September 2003. The 10th percentile of risk for ICS/LABA between 11 September 2005–10 Septmeber 2007 was associated with a 3.32-fold increased hazard of actual ICS/LABA initiation in the subsequent 4 years. In firefighters with WTC exposure, FEV₁, wheeze, and dyspnea were independently associated with prolonged ICS/LABA treatment. A high risk for treatment was identifiable from routine monitoring exam results years before treatment initiation.

Original language	English (US)
Article number	9056
Pages (from-to)	1-11
Number of pages	11
Journal	International journal of environmental research and public health
Volume	17
Issue number	23
DOIs	https://doi.org/10.3390/ijerph17239056
State	Published - Dec 1 2020

Keywords

Epidemiological studies
Inhalation therapy
Lung injury
Occupational exposure
Pulmonary function tests

ASJC Scopus subject areas

Pollution
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph17239056

Cite this

Putman, B., Lahousse, L., Goldfarb, D. G., Zeig-Owens, R., Schwartz, T., Singh, A., Vaeth, B., Hall, C. B., Lancet, E. A., Webber, M. P., Cohen, H. W., Prezant, D. J., & Weiden, M. D. (2020). Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study. International journal of environmental research and public health, 17(23), 1-11. Article 9056. https://doi.org/10.3390/ijerph17239056

Putman, B, Lahousse, L, Goldfarb, DG, Zeig-Owens, R, Schwartz, T, Singh, A, Vaeth, B, Hall, CB, Lancet, EA, Webber, MP, Cohen, HW, Prezant, DJ & Weiden, MD 2020, 'Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study', International journal of environmental research and public health, vol. 17, no. 23, 9056, pp. 1-11. https://doi.org/10.3390/ijerph17239056

@article{a857d722bf5847a0afc2fa8a9324bd85,

title = "Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study",

abstract = "The factors that predict treatment of lung injury in occupational cohorts are poorly defined. We aimed to identify patient characteristics associated with initiation of treatment with inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) >2 years among World Trade Center (WTC)-exposed firefighters. The study population included 8530 WTC-exposed firefighters. Multivariable logistic regression assessed the association of patient characteristics with ICS/LABA treatment for >2 years over two-year intervals from 11 September 2001–10 September 2017. Cox proportional hazards models measured the association of high probability of ICS/LABA initiation with actual ICS/LABA initiation in subsequent intervals. Between 11 September 2001–1 July 2018, 1629/8530 (19.1%) firefighters initiated ICS/LABA treatment for >2 years. Forced Expiratory Volume in 1 s (FEV1), wheeze, and dyspnea were consistently and independently associated with ICS/LABA treatment. High-intensity WTC exposure was associated with ICS/LABA between 11 September 2001– 10 September 2003. The 10th percentile of risk for ICS/LABA between 11 September 2005–10 Septmeber 2007 was associated with a 3.32-fold increased hazard of actual ICS/LABA initiation in the subsequent 4 years. In firefighters with WTC exposure, FEV1, wheeze, and dyspnea were independently associated with prolonged ICS/LABA treatment. A high risk for treatment was identifiable from routine monitoring exam results years before treatment initiation.",

keywords = "Epidemiological studies, Inhalation therapy, Lung injury, Occupational exposure, Pulmonary function tests",

author = "Barbara Putman and Lies Lahousse and Goldfarb, {David G.} and Rachel Zeig-Owens and Theresa Schwartz and Ankura Singh and Brandon Vaeth and Hall, {Charles B.} and Lancet, {Elizabeth A.} and Webber, {Mayris P.} and Cohen, {Hillel W.} and Prezant, {David J.} and Weiden, {Michael D.}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = dec,

day = "1",

doi = "10.3390/ijerph17239056",

language = "English (US)",

volume = "17",

pages = "1--11",

journal = "International journal of environmental research and public health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "23",

}

TY - JOUR

T1 - Factors predicting treatment of world trade center-related lung injury

T2 - A longitudinal cohort study

AU - Putman, Barbara

AU - Lahousse, Lies

AU - Goldfarb, David G.

AU - Zeig-Owens, Rachel

AU - Schwartz, Theresa

AU - Singh, Ankura

AU - Vaeth, Brandon

AU - Hall, Charles B.

AU - Lancet, Elizabeth A.

AU - Webber, Mayris P.

AU - Cohen, Hillel W.

AU - Prezant, David J.

AU - Weiden, Michael D.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The factors that predict treatment of lung injury in occupational cohorts are poorly defined. We aimed to identify patient characteristics associated with initiation of treatment with inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) >2 years among World Trade Center (WTC)-exposed firefighters. The study population included 8530 WTC-exposed firefighters. Multivariable logistic regression assessed the association of patient characteristics with ICS/LABA treatment for >2 years over two-year intervals from 11 September 2001–10 September 2017. Cox proportional hazards models measured the association of high probability of ICS/LABA initiation with actual ICS/LABA initiation in subsequent intervals. Between 11 September 2001–1 July 2018, 1629/8530 (19.1%) firefighters initiated ICS/LABA treatment for >2 years. Forced Expiratory Volume in 1 s (FEV1), wheeze, and dyspnea were consistently and independently associated with ICS/LABA treatment. High-intensity WTC exposure was associated with ICS/LABA between 11 September 2001– 10 September 2003. The 10th percentile of risk for ICS/LABA between 11 September 2005–10 Septmeber 2007 was associated with a 3.32-fold increased hazard of actual ICS/LABA initiation in the subsequent 4 years. In firefighters with WTC exposure, FEV1, wheeze, and dyspnea were independently associated with prolonged ICS/LABA treatment. A high risk for treatment was identifiable from routine monitoring exam results years before treatment initiation.

AB - The factors that predict treatment of lung injury in occupational cohorts are poorly defined. We aimed to identify patient characteristics associated with initiation of treatment with inhaled corticosteroid/long-acting beta-agonist (ICS/LABA) >2 years among World Trade Center (WTC)-exposed firefighters. The study population included 8530 WTC-exposed firefighters. Multivariable logistic regression assessed the association of patient characteristics with ICS/LABA treatment for >2 years over two-year intervals from 11 September 2001–10 September 2017. Cox proportional hazards models measured the association of high probability of ICS/LABA initiation with actual ICS/LABA initiation in subsequent intervals. Between 11 September 2001–1 July 2018, 1629/8530 (19.1%) firefighters initiated ICS/LABA treatment for >2 years. Forced Expiratory Volume in 1 s (FEV1), wheeze, and dyspnea were consistently and independently associated with ICS/LABA treatment. High-intensity WTC exposure was associated with ICS/LABA between 11 September 2001– 10 September 2003. The 10th percentile of risk for ICS/LABA between 11 September 2005–10 Septmeber 2007 was associated with a 3.32-fold increased hazard of actual ICS/LABA initiation in the subsequent 4 years. In firefighters with WTC exposure, FEV1, wheeze, and dyspnea were independently associated with prolonged ICS/LABA treatment. A high risk for treatment was identifiable from routine monitoring exam results years before treatment initiation.

KW - Epidemiological studies

KW - Inhalation therapy

KW - Lung injury

KW - Occupational exposure

KW - Pulmonary function tests

UR - http://www.scopus.com/inward/record.url?scp=85097314730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85097314730&partnerID=8YFLogxK

U2 - 10.3390/ijerph17239056

DO - 10.3390/ijerph17239056

M3 - Article

C2 - 33291671

AN - SCOPUS:85097314730

SN - 1661-7827

VL - 17

SP - 1

EP - 11

JO - International journal of environmental research and public health

JF - International journal of environmental research and public health

IS - 23

M1 - 9056

ER -

Factors predicting treatment of world trade center-related lung injury: A longitudinal cohort study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this