TY - JOUR
T1 - Factor analysis of repetitive behaviors in autism as measured by the Y-BOCS
AU - Anagnostou, Evdokia
AU - Chaplin, William
AU - Watner, Dryden
AU - Silverman, Jeremy M.
AU - Smith, Christopher J.
AU - Zagursky, Karen
AU - Kryzak, Lauren A.
AU - Corwin, Thomas E.
AU - Feirsen, Nicole
AU - Tanel, Nadia
AU - Hollander, Eric
PY - 2011
Y1 - 2011
N2 - The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at the category level in order to reduce the number of variables in this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. The authors estimated a tetrachoric correlation matrix among the dichotomous symptom categories and then used exploratory and confirmatory factor analyses to identify a clinically meaningful factor structure for this correlation matrix. Their analysis supported a four-factor solution: obsessions, higher-order repetitive behaviors, lower-order repetitive behaviors, and hoarding. These findings are another step in the effort to identify genetically and biologically distinct groups within this population.
AB - The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at the category level in order to reduce the number of variables in this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. The authors estimated a tetrachoric correlation matrix among the dichotomous symptom categories and then used exploratory and confirmatory factor analyses to identify a clinically meaningful factor structure for this correlation matrix. Their analysis supported a four-factor solution: obsessions, higher-order repetitive behaviors, lower-order repetitive behaviors, and hoarding. These findings are another step in the effort to identify genetically and biologically distinct groups within this population.
UR - http://www.scopus.com/inward/record.url?scp=80054967579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054967579&partnerID=8YFLogxK
U2 - 10.1176/jnp.23.3.jnp332
DO - 10.1176/jnp.23.3.jnp332
M3 - Article
C2 - 21948895
AN - SCOPUS:80054967579
SN - 0895-0172
VL - 23
SP - 332
EP - 339
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -