Extra-corporeal membrane oxygenation for paediatric respiratory failure

G. J. Peek; A. W. Sosnowski

doi:10.1093/oxfordjournals.bmb.a011645

Extra-corporeal membrane oxygenation for paediatric respiratory failure

G. J. Peek, A. W. Sosnowski

Cardiovascular & Thoracic Surgery

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Extracorporeal membrane oxygenation (ECMO) uses modified cardiopulmonary bypass technology to provide prolonged respiratory or cardiorespiratory support for patients of all ages who have failed conventional intensive care management. The use of ECMO for neonatal respiratory failure is now evidence-based following the publication of the randomised UK Collaborative Trial. ECMO use in children remains more controversial, but overall survival of 71% is possible in a group of moribund patients whose mean PaO₂/FlO₂ ratio of 61 mmHg accurately predicts death in studies of conventional ventilation. Common diagnoses for children requiring ECMO support are pneumonia and the acute respiratory distress syndrome (ARDS).

Original language	English (US)
Pages (from-to)	745-756
Number of pages	12
Journal	British Medical Bulletin
Volume	53
Issue number	4
DOIs	https://doi.org/10.1093/oxfordjournals.bmb.a011645
State	Published - 1997

ASJC Scopus subject areas

Medicine(all)

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10.1093/oxfordjournals.bmb.a011645

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@article{dde2d41fce144629b40c0605b2f4af2a,

title = "Extra-corporeal membrane oxygenation for paediatric respiratory failure",

abstract = "Extracorporeal membrane oxygenation (ECMO) uses modified cardiopulmonary bypass technology to provide prolonged respiratory or cardiorespiratory support for patients of all ages who have failed conventional intensive care management. The use of ECMO for neonatal respiratory failure is now evidence-based following the publication of the randomised UK Collaborative Trial. ECMO use in children remains more controversial, but overall survival of 71% is possible in a group of moribund patients whose mean PaO2/FlO2 ratio of 61 mmHg accurately predicts death in studies of conventional ventilation. Common diagnoses for children requiring ECMO support are pneumonia and the acute respiratory distress syndrome (ARDS).",

author = "Peek, {G. J.} and Sosnowski, {A. W.}",

note = "Funding Information: Hill's success generated wide interest in adult ECMO leading to the US National Institutes of Health (NIH) study in the mid 1970s10'11. This was a national multi-centre trial in which patients with severe respiratory failure who fulfilled certain 'ECMO criteria' (fast entry — PaO2 <50mmHg with FIO2 1 cmH2O and PEEP >5 cmH2O: slow entry —PaO2 <50mmHg for > 12 h with FIO2 >0.6 cmH2O and PEEP >5 cmH2O and shunt fraction >30%) were randomised to either receive ECMO or continue on conventional treatment. The trial was curtailed because of high mortality in both groups (91.7% conventional and 86.4% ECMO).",

year = "1997",

doi = "10.1093/oxfordjournals.bmb.a011645",

language = "English (US)",

volume = "53",

pages = "745--756",

journal = "British Medical Bulletin",

issn = "0007-1420",

publisher = "Oxford University Press",

number = "4",

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T1 - Extra-corporeal membrane oxygenation for paediatric respiratory failure

AU - Peek, G. J.

AU - Sosnowski, A. W.

N1 - Funding Information: Hill's success generated wide interest in adult ECMO leading to the US National Institutes of Health (NIH) study in the mid 1970s10'11. This was a national multi-centre trial in which patients with severe respiratory failure who fulfilled certain 'ECMO criteria' (fast entry — PaO2 <50mmHg with FIO2 1 cmH2O and PEEP >5 cmH2O: slow entry —PaO2 <50mmHg for > 12 h with FIO2 >0.6 cmH2O and PEEP >5 cmH2O and shunt fraction >30%) were randomised to either receive ECMO or continue on conventional treatment. The trial was curtailed because of high mortality in both groups (91.7% conventional and 86.4% ECMO).

PY - 1997

Y1 - 1997

N2 - Extracorporeal membrane oxygenation (ECMO) uses modified cardiopulmonary bypass technology to provide prolonged respiratory or cardiorespiratory support for patients of all ages who have failed conventional intensive care management. The use of ECMO for neonatal respiratory failure is now evidence-based following the publication of the randomised UK Collaborative Trial. ECMO use in children remains more controversial, but overall survival of 71% is possible in a group of moribund patients whose mean PaO2/FlO2 ratio of 61 mmHg accurately predicts death in studies of conventional ventilation. Common diagnoses for children requiring ECMO support are pneumonia and the acute respiratory distress syndrome (ARDS).

AB - Extracorporeal membrane oxygenation (ECMO) uses modified cardiopulmonary bypass technology to provide prolonged respiratory or cardiorespiratory support for patients of all ages who have failed conventional intensive care management. The use of ECMO for neonatal respiratory failure is now evidence-based following the publication of the randomised UK Collaborative Trial. ECMO use in children remains more controversial, but overall survival of 71% is possible in a group of moribund patients whose mean PaO2/FlO2 ratio of 61 mmHg accurately predicts death in studies of conventional ventilation. Common diagnoses for children requiring ECMO support are pneumonia and the acute respiratory distress syndrome (ARDS).

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U2 - 10.1093/oxfordjournals.bmb.a011645

DO - 10.1093/oxfordjournals.bmb.a011645

M3 - Review article

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SN - 0007-1420

VL - 53

SP - 745

EP - 756

JO - British Medical Bulletin

JF - British Medical Bulletin

IS - 4

ER -

Extra-corporeal membrane oxygenation for paediatric respiratory failure

Abstract

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