TY - JOUR
T1 - Exploring the dynamic behavior of leukocytes with zebrafish
AU - Michael, Cassia
AU - de Oliveira, Sofia
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/12
Y1 - 2023/12
N2 - Cell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligned to transparency that enables modulation and visualization of cell migration in vivo noninvasively. Such characteristics revolutionized the field of leukocyte biology, particularly neutrophils. In this review, we will focus on leukocyte migration and highlight findings made in the zebrafish that demonstrate how this small vertebrate system is a unique model to perform in vivo imaging and study mechanisms that regulate the dynamic behavior of immune cells in their native environment under homeostasis or upon challenge.
AB - Cell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligned to transparency that enables modulation and visualization of cell migration in vivo noninvasively. Such characteristics revolutionized the field of leukocyte biology, particularly neutrophils. In this review, we will focus on leukocyte migration and highlight findings made in the zebrafish that demonstrate how this small vertebrate system is a unique model to perform in vivo imaging and study mechanisms that regulate the dynamic behavior of immune cells in their native environment under homeostasis or upon challenge.
KW - Cell migration
KW - Non-invasive imaging
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85176470315&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85176470315&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2023.102276
DO - 10.1016/j.ceb.2023.102276
M3 - Review article
C2 - 37956533
AN - SCOPUS:85176470315
SN - 0955-0674
VL - 85
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
M1 - 102276
ER -