Examination of the SGCE gene in Tourette's syndrome patients with obsessive-compulsive disorder

Patricia de Carvalho Aguiar, Melissa Fazzari, Joseph Jankovic, Laurie J. Ozelius

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Mutations in the ε-sarcoglycan gene (SGCE) have been reported in families with myoclonus-dystonia (M-D). In addition to abnormal movements, obsessive-compulsive disorder (OCD) has also been described in families with M-D. OCD is a common feature in another movement disorder, namely Tourette's syndrome (TS). The comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method.

Original languageEnglish (US)
Pages (from-to)1237-1238
Number of pages2
JournalMovement Disorders
Issue number10
StatePublished - Oct 2004


  • Myoclonus-dystonia
  • Obsessive-compulsive disorder
  • Tourette's syndrome
  • ε-sarcoglycan

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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