Evolving challenges to model human diseases for translational research

Amanda P. Beck, David K. Meyerholz

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have been significant changes in the landscape of animal modeling. For example, newer techniques have greatly expanded the use and successful application of large animal models such as pigs for translational studies. The evolving types and species of animal models can influence the research landscape in terms of facilities, expertise, reproducibility and funding streams, which creates new challenges for research studies. It is also important that investigators are prepared to address the necessity of their animal model research and capable to educate the public regarding its value.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalCell and Tissue Research
Issue number2
StatePublished - May 1 2020


  • Animal models
  • Biomedical research
  • Large animal models
  • Translation
  • Translational studies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology


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