Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Jie Ma; Jian Sun; Huan Zhang; Rui Zhang; Wan Hu Kang; Cheng Ge Gao; Hai Sheng Liu; Xue Hong Ma; Zi Xin Min; Wen Xiang Zhao; Qi Lan Ning; Shu Hong Wang; Yin Cang Zhang; Ting Wei Guo; She Min Lu

doi:10.1016/j.neulet.2009.06.070

Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

Jie Ma, Jian Sun, Huan Zhang, Rui Zhang, Wan Hu Kang, Cheng Ge Gao, Hai Sheng Liu, Xue Hong Ma, Zi Xin Min, Wen Xiang Zhao, Qi Lan Ning, Shu Hong Wang, Yin Cang Zhang, Ting Wei Guo, She Min Lu

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

Original language	English (US)
Pages (from-to)	105-108
Number of pages	4
Journal	Neuroscience Letters
Volume	462
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2009.06.070
State	Published - Sep 22 2009
Externally published	Yes

Keywords

Association
DAOA
Haplotype
SNP
Schizophrenia
TDT

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2009.06.070

Cite this

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title = "Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample",

abstract = "Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.",

keywords = "Association, DAOA, Haplotype, SNP, Schizophrenia, TDT",

author = "Jie Ma and Jian Sun and Huan Zhang and Rui Zhang and Kang, {Wan Hu} and Gao, {Cheng Ge} and Liu, {Hai Sheng} and Ma, {Xue Hong} and Min, {Zi Xin} and Zhao, {Wen Xiang} and Ning, {Qi Lan} and Wang, {Shu Hong} and Zhang, {Yin Cang} and Guo, {Ting Wei} and Lu, {She Min}",

note = "Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the National Natural Science Foundation of China (No. 30800618), the Chinese Ministry of Education, PRC, and the Headmaster Foundation of Xi{\textquoteright}an Jiaotong University.",

year = "2009",

month = sep,

day = "22",

doi = "10.1016/j.neulet.2009.06.070",

language = "English (US)",

volume = "462",

pages = "105--108",

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AU - Ma, Jie

AU - Sun, Jian

AU - Zhang, Huan

AU - Zhang, Rui

AU - Kang, Wan Hu

AU - Gao, Cheng Ge

AU - Liu, Hai Sheng

AU - Ma, Xue Hong

AU - Min, Zi Xin

AU - Zhao, Wen Xiang

AU - Ning, Qi Lan

AU - Wang, Shu Hong

AU - Zhang, Yin Cang

AU - Guo, Ting Wei

AU - Lu, She Min

N1 - Funding Information: We are deeply grateful to all of the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the National Natural Science Foundation of China (No. 30800618), the Chinese Ministry of Education, PRC, and the Headmaster Foundation of Xi’an Jiaotong University.

PY - 2009/9/22

Y1 - 2009/9/22

N2 - Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

AB - Recently, the DAOA gene locus on chromosome 13q32-q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.

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Evidence for transmission disequilibrium at the DAOA gene locus in a schizophrenia family sample

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Keywords

ASJC Scopus subject areas

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