Evidence for central regulation of glucose metabolism

Michelle Carey, Sylvia Kehlenbrink, Meredith Hawkins

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Evidence for central regulation of glucose homeostasis is accumulating from both animal and human studies. Central nutrient and hormone sensing in the hypothalamus appears to coordinate regulation of whole body metabolism. Central signals activate ATP-sensitive potassium (KATP) channels, thereby down-regulating glucose production, likely through vagal efferent signals. Recent human studies are consistent with this hypothesis. The contributions of direct and central inputs to metabolic regulation are likely of comparable magnitude, with somewhat delayed central effects and more rapid peripheral effects. Understanding central regulation of glucose metabolism could promote the development of novel therapeutic approaches for such metabolic conditions as diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)35387-35395
Number of pages9
JournalJournal of Biological Chemistry
Issue number49
StatePublished - Dec 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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