Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls

Vivian L. Chin, Ziyong Cai, Leslie Lam, Bina Shah, Ping Zhou

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test. Objective: To determine the best predictive model for detecting puberty in girls. Subjects: Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche/premature adrenarche (n=15). Methods: Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed. Results: The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%. Conclusions: The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number3-4
StatePublished - Mar 1 2015


  • GnRHa stimulation testing
  • central precocious puberty
  • girls
  • leuprolide stimulation test

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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