Evaluation of polylactic acid-carbon mesh for repair of ventral herniorrhaphy

Stuart M. Greenstein, Thomas F. Murphy, Benjamin F. Rush, Harold Alexander

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Large ventral hernias are a difficult surgical problem. Previous attempts to repair large defects in the abdominal wall with prostheses have been associated with recurrences and infection. A filamentous polylactic acid-carbon tissue mesh is a possible alternative prosthesis. We evaluated and compared polylactic acid-carbon mesh and Marlex mesh in repairing a large defect of the abdominal wall in a rat model. The polylactic acid-carbon mesh led to as strong a repair as Marlex mesh for the same time periods postoperatively; furthermore, no infection was noted with the former, whereas a 5.3 percent incidence of infection was noted with Marlex mesh. One mesh disruption was also noted with Marlex mesh. Polylactic acid-carbon mesh was found to have a more marked fibrotic response and a lesser inflammatory response. Polylactic acid-carbon mesh, therefore, appears to be more biocompatible, with more fibrosis, less inflammatory reaction, and equal strength to Marlex mesh. It is therefore a more appropriate synthetic material for a large ventral herniorrhaphy.

Original languageEnglish (US)
Pages (from-to)635-639
Number of pages5
JournalThe American Journal of Surgery
Issue number5
StatePublished - May 1986
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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