| Original language | English (US) |
|---|---|
| Pages (from-to) | 60-64 |
| Number of pages | 5 |
| Journal | Practical Gastroenterology |
| Volume | 42 |
| Issue number | 5 |
| State | Published - May 2018 |
ASJC Scopus subject areas
- Gastroenterology
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In: Practical Gastroenterology, Vol. 42, No. 5, 05.2018, p. 60-64.
Research output: Contribution to journal › Comment/debate › peer-review
}
TY - JOUR
T1 - Esophageal dieulafoy lesion
T2 - A rare cause of upper gastrointestinal bleeding
AU - Haider, Tehseen
AU - Guddati, Harish
AU - Hertang, Hilary
N1 - Funding Information: New oY rk, NY – A break-through discovery being reported in the February online issue of Science Magazine advances our understanding of the genetic causes of ulcerative colitis. The research, funded by the Crohns’ & Colitis Foundation (the Foundation), and conducted by investigators at Massachusetts General Hospital and the Broad Institute, reveals a genetic variant associated with ulcerative colitis (a form of Inflammatory bowel disease (IBD) that controls the intestinal barrier. The finding could lead to new therapeutics that would restore patients’ normal intestinal functioning to relieve symptoms and put their disease into remission. The new study, led by Ramnik X vier, MD, PhD, Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at Massachusetts General Hospital and Kara Lassen, Ph.D., Research Scientist at The Broad Institute, identifies the mechanism by which a genetic change to a single protein produced by the C1ORF106 gene (a largely uncharacterized gene known to contain genetic variants that confer risk for ulcerative colitis) can alter the junctions that connect cells to form the lining of the human gut, resulting in impaired intestinal barrier function, or “leaky gut.” The fact that this condition has been observed in patients with ulcerative colitis, as well as in healthy family members of some patients, suggests a genetic component might underlie the phenomenon.
PY - 2018/5
Y1 - 2018/5
UR - http://www.scopus.com/inward/record.url?scp=85073344020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073344020&partnerID=8YFLogxK
M3 - Comment/debate
AN - SCOPUS:85073344020
SN - 0277-4208
VL - 42
SP - 60
EP - 64
JO - Practical Gastroenterology
JF - Practical Gastroenterology
IS - 5
ER -