Abstract
The large repertoire of antibodies that is achieved through V(D)J recombination does not create antibodies that have sufficient affinity and broad enough specificity to protect against all toxins and pathogenic organisms. To create such antibodies, B cells somatically hypermutate the antibody variable regions to increase affinity and the Ig switch regions to express those mutated variable regions with each of the isotypes through class switch recombination. This article focuses on how somatic mutations generated by activation-induced deaminase in the variable and switch regions are extended by noncanonical error-prone mismatch and base excision repair.
Original language | English (US) |
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Title of host publication | Molecular Immunology |
Publisher | Elsevier Inc. |
Pages | 126-133 |
Number of pages | 8 |
Volume | 2 |
ISBN (Print) | 9780080921525 |
DOIs | |
State | Published - Apr 27 2016 |
Keywords
- AID
- Antibody diversification
- Base excision DNA repair
- Class switch recombination
- DNA mismatch repair
- Double-strand break
- Error-prone polymerase
- Germinal center
- Hotspot
- Somatic hypermutation
- Variable regions
ASJC Scopus subject areas
- General Medicine