Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

William J. Sullivan; Joshua B. Radke; Kami Kim; Michael W. White

doi:10.1016/B978-0-12-396481-6.00018-0

Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

William J. Sullivan, Joshua B. Radke, Kami Kim, Michael W. White

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

Original language	English (US)
Title of host publication	Toxoplasma Gondii
Subtitle of host publication	The Model Apicomplexan - Perspectives and Methods: Second Edition
Publisher	Elsevier Ltd.
Pages	613-645
Number of pages	33
ISBN (Print)	9780123964816
DOIs	https://doi.org/10.1016/B978-0-12-396481-6.00018-0
State	Published - Sep 2013

Keywords

APETELA (AP2)
Chromatin remodeling
Epigenetics
Histone modification
Transcription
Transcription factor
Translational regulation

ASJC Scopus subject areas

Immunology and Microbiology(all)

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10.1016/B978-0-12-396481-6.00018-0

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title = "Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii",

abstract = "As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.",

keywords = "APETELA (AP2), Chromatin remodeling, Epigenetics, Histone modification, Transcription, Transcription factor, Translational regulation",

author = "Sullivan, {William J.} and Radke, {Joshua B.} and Kami Kim and White, {Michael W.}",

note = "Funding Information: Research in our laboratories is supported by the following grants: NIH AI77502 (to WJS), AI087625 (to KK), AI077662 and AI089885 (to MWW) and RC4 AI092801 (to KK, WJS, MWW). We thank Sheila Nardelli for preparation of Fig. 18.2 . Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "2013",

month = sep,

doi = "10.1016/B978-0-12-396481-6.00018-0",

language = "English (US)",

isbn = "9780123964816",

pages = "613--645",

booktitle = "Toxoplasma Gondii",

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T1 - Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

AU - Sullivan, William J.

AU - Radke, Joshua B.

AU - Kim, Kami

AU - White, Michael W.

N1 - Funding Information: Research in our laboratories is supported by the following grants: NIH AI77502 (to WJS), AI087625 (to KK), AI077662 and AI089885 (to MWW) and RC4 AI092801 (to KK, WJS, MWW). We thank Sheila Nardelli for preparation of Fig. 18.2 . Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2013/9

Y1 - 2013/9

N2 - As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

AB - As it passes through its life-cycle and different hosts, Toxoplasma gondii must sense and respond to changes in its environment. T. gondii life cycle transitions and cell cycle changes are accompanied by major changes in gene expression and the parasite transcriptome. While many of the components of the general transcription machinery are conserved, few classic transcription factors were identified until the ApiAP2 APETELA plant-like transcription family was discovered. Gene expression, including bradyzoite differentiation, is also controlled by epigenetic factors. This chapter reviews current efforts to understand the role of ApiAP2 in transcriptional regulation and the importance of epigenetic factors and post-transcriptional mechanisms of gene regulation in Toxoplasma.

KW - APETELA (AP2)

KW - Chromatin remodeling

KW - Epigenetics

KW - Histone modification

KW - Transcription

KW - Transcription factor

KW - Translational regulation

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U2 - 10.1016/B978-0-12-396481-6.00018-0

DO - 10.1016/B978-0-12-396481-6.00018-0

M3 - Chapter

AN - SCOPUS:84904087274

SN - 9780123964816

SP - 613

EP - 645

BT - Toxoplasma Gondii

PB - Elsevier Ltd.

ER -

Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii

Abstract

Keywords

ASJC Scopus subject areas

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