Epidemiology and control of vancomycin-resistant enterococci in a regional neonatal intensive care unit

Rajesh K. Malik, Marisa A. Montecalvo, Mario R. Reale, Karl Li, Myint Maw, Jose L. Munoz, Cheryl Gedris, Ken Van Horn, Kevin A. Carnevale, Michael H. Levi, Harry S. Dweck

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Background. After the occurrence of two cases of bloodstream infection with vancomycin-resistant enterococci (VRE) in our regional neonatal intensive care unit, we studied the epidemiology of VRE and applied extensive infection control measures to the unit to control VRE transmission. Methods. Infection control measures applied to the unit included weekly surveillance for VRE colonization; education; cohorting of VRE-positive, VRE-negative and VRE-exposed babies with separate personnel and equipment for each group; use of gowns and gloves on room entry; and hand washing before and after each patient contact. Risk factors for VRE colonization were determined with a stepwise logistic regression model. Results. Thirty-three (40.2%) babies became colonized with VRE. The VRE colonization rate was reduced from 67% to 7% after implementation of infection control measures. Prolonged antimicrobial treatment and low birth weight were significantly associated with an increased risk of VRE colonization. Conclusion. VRE can spread rapidly among newborns in a regional neonatal intensive care unit. Strict infection control measures can reduce the rate of VRE colonization among neonates.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalPediatric Infectious Disease Journal
Issue number4
StatePublished - Apr 1999


  • Colonization
  • Neonatal intensive care unit
  • Vancomycin-resistant enterococci

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


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