TY - JOUR
T1 - Epicardial fat volume in patients with left ventricular systolic dysfunction
AU - Khawaja, Tuba
AU - Greer, Christine
AU - Chokshi, Aalap
AU - Chavarria, Nelson
AU - Thadani, Samir
AU - Jones, Meaghan
AU - Schaefle, Kenneth
AU - Bhatia, Ketan
AU - Collado, J. Elias
AU - Shimbo, Daichi
AU - Einstein, Andrew J.
AU - Schulze, P. Christian
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Epicardial adipose tissue has been linked to cardiovascular metabolism and inflammation and has been shown to predict prevalence and progression of coronary artery disease. Only limited data are available on the role of epicardial fat in patients with heart failure (HF). We analyzed cardiac adiposity and its relation to markers of morbidity and clinical outcome in patients with normal and impaired left ventricular (LV) function. Epicardial fat volume (EFV) and coronary artery calcium were measured in 381 patients (210 women and 171 men, mean age 55 ± 10 years) who underwent low-dose computed tomography. HF was defined by LV ejection fraction (EF) <55%. Three hundred twenty-one patients had an EF >55% (mean 63 ± 6) and 60 patients had an EF <55% (mean 41 ± 12). Subgroup analysis was performed according to degree of LV dysfunction in patients with HF (LVEF 35% to 55% or <35%). Mean EFVs were 114.5 ± 98.5 cm3 in patients with normal EF and 83.5 ± 67.1 cm3 in those with decreased EF (p <0.05). Mean EFVs were 96.1 ± 73.9 cm3 in patients with moderate HF and 52.2 ± 29.7 cm3 in patients with severe HF (p <0.05). Subgroup analysis revealed a persistently smaller EFV in patients with HF regardless of coronary artery calcium scores, markers of renal function, lipid metabolism, fasting blood glucose, or body mass index. In conclusion, our data demonstrate a stepwise decrease in EFV in patients with impaired cardiac function.
AB - Epicardial adipose tissue has been linked to cardiovascular metabolism and inflammation and has been shown to predict prevalence and progression of coronary artery disease. Only limited data are available on the role of epicardial fat in patients with heart failure (HF). We analyzed cardiac adiposity and its relation to markers of morbidity and clinical outcome in patients with normal and impaired left ventricular (LV) function. Epicardial fat volume (EFV) and coronary artery calcium were measured in 381 patients (210 women and 171 men, mean age 55 ± 10 years) who underwent low-dose computed tomography. HF was defined by LV ejection fraction (EF) <55%. Three hundred twenty-one patients had an EF >55% (mean 63 ± 6) and 60 patients had an EF <55% (mean 41 ± 12). Subgroup analysis was performed according to degree of LV dysfunction in patients with HF (LVEF 35% to 55% or <35%). Mean EFVs were 114.5 ± 98.5 cm3 in patients with normal EF and 83.5 ± 67.1 cm3 in those with decreased EF (p <0.05). Mean EFVs were 96.1 ± 73.9 cm3 in patients with moderate HF and 52.2 ± 29.7 cm3 in patients with severe HF (p <0.05). Subgroup analysis revealed a persistently smaller EFV in patients with HF regardless of coronary artery calcium scores, markers of renal function, lipid metabolism, fasting blood glucose, or body mass index. In conclusion, our data demonstrate a stepwise decrease in EFV in patients with impaired cardiac function.
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U2 - 10.1016/j.amjcard.2011.03.058
DO - 10.1016/j.amjcard.2011.03.058
M3 - Article
C2 - 21565323
AN - SCOPUS:79960377550
SN - 0002-9149
VL - 108
SP - 397
EP - 401
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -