Enhancement of presynaptic dopamine efflux in brain by Δ9-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism

E. L. Gardner; J. Chen; W. Paredes; D. Smith; J. Li; J. Lowinson

Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism

E. L. Gardner, J. Chen, W. Paredes, D. Smith, J. Li, J. Lowinson

Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

The opiate antagonist naloxone, at doses as low as 0.1 mg/kg, antagonizes the enhancing effect of Δ⁹-tetrahydrocannabinol, the psychoactive agent in marijuana, on dopamine efflux in brain-reward-relevant dopamine circuits, implicating an endogenous opioid mechanism in marijuana's euphorigenic effect.

Original language	English (US)
Title of host publication	New leads in opioid research
Subtitle of host publication	proceedings of the International Narcotics Research Conference. ICS914
Editors	J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
Publisher	Elsevier Science Publishers B.V.
Number of pages	1
ISBN (Print)	044481213X
State	Published - Jan 1 1990
Event	The International Narcotics Research Conference - Duration: Jul 8 1989 → Jul 13 1989

Publication series

Name	New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

Other	The International Narcotics Research Conference
Period	7/8/89 → 7/13/89

ASJC Scopus subject areas

Medicine(all)

Cite this

Gardner, E. L., Chen, J., Paredes, W., Smith, D., Li, J., & Lowinson, J. (1990). Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..

Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. / Gardner, E. L.; Chen, J.; Paredes, W. et al.
New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gardner, EL, Chen, J, Paredes, W, Smith, D, Li, J & Lowinson, J 1990, Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914, Elsevier Science Publishers B.V., The International Narcotics Research Conference, 7/8/89.

Gardner EL, Chen J, Paredes W, Smith D, Li J, Lowinson J. Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

Gardner, E. L. ; Chen, J. ; Paredes, W. et al. / Enhancement of presynaptic dopamine efflux in brain by Δ⁹-tetrahydro-cannabinol is mediated by an endogenous opioid mechanism. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

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