Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Ruby Bansal; Rajiv Pathak; Diksha Jha; Pradeep Kumar; Hemant K. Gautam

doi:10.1080/00914037.2014.886246

Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Ruby Bansal, Rajiv Pathak, Diksha Jha, Pradeep Kumar, Hemant K. Gautam

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

Original language	English (US)
Pages (from-to)	84-89
Number of pages	6
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	64
Issue number	2
DOIs	https://doi.org/10.1080/00914037.2014.886246
State	Published - Jul 20 2015
Externally published	Yes

Keywords

Antimicrobial activity
cationic polymers
linear polyethylenimine
phosphonium salts

ASJC Scopus subject areas

Analytical Chemistry
Chemical Engineering(all)
Polymers and Plastics

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10.1080/00914037.2014.886246

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title = "Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria",

abstract = "The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.",

keywords = "Antimicrobial activity, cationic polymers, linear polyethylenimine, phosphonium salts",

author = "Ruby Bansal and Rajiv Pathak and Diksha Jha and Pradeep Kumar and Gautam, {Hemant K.}",

note = "Funding Information: Financial support from the CSIR network projects BSC0302 and BSC0120 is gratefully acknowledged. Drs. Bansal and Pathak also thank CSIR and UGC, respectively, for providing Senior Research Fellowships to carry out this work. Publisher Copyright: {\textcopyright} 2015 Taylor & Francis Group, LLC.",

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doi = "10.1080/00914037.2014.886246",

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T1 - Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

AU - Bansal, Ruby

AU - Pathak, Rajiv

AU - Jha, Diksha

AU - Kumar, Pradeep

AU - Gautam, Hemant K.

N1 - Funding Information: Financial support from the CSIR network projects BSC0302 and BSC0120 is gratefully acknowledged. Drs. Bansal and Pathak also thank CSIR and UGC, respectively, for providing Senior Research Fellowships to carry out this work. Publisher Copyright: © 2015 Taylor & Francis Group, LLC.

PY - 2015/7/20

Y1 - 2015/7/20

N2 - The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

AB - The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with ∼5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains.

KW - Antimicrobial activity

KW - cationic polymers

KW - linear polyethylenimine

KW - phosphonium salts

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Enhanced antimicrobial activity of amine-phosphonium (N-P) hybrid polymers against gram-negative and gram-positive bacteria

Abstract

Keywords

ASJC Scopus subject areas

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