TY - JOUR
T1 - Endothelial Extracellular Vesicles Enriched in microRNA-34a Predict New-Onset Diabetes in Coronavirus Disease 2019 (COVID-19) Patients
T2 - Novel Insights for Long COVID Metabolic Sequelae
AU - Mone, Pasquale
AU - Jankauskas, Stanislovas S.
AU - Manzi, Maria Virginia
AU - Gambardella, Jessica
AU - Coppola, Antonietta
AU - Kansakar, Urna
AU - Izzo, Raffaele
AU - Fiorentino, Giuseppe
AU - Lombardi, Angela
AU - Varzideh, Fahimeh
AU - Sorriento, Daniela
AU - Trimarco, Bruno
AU - Santulli, Gaetano
N1 - Publisher Copyright:
© 2024 by The American Society for Pharmacology and Experimental Therapeutics.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Emerging evidence indicates that the relationship between coronavirus disease 2019 (COVID-19) and diabetes is 2-fold: 1) it is known that the presence of diabetes and other metabolic alterations poses a considerably high risk to develop a severe COVID-19; 2) patients who survived a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an increased risk of developing new-onset diabetes. However, the mechanisms underlying this association are mostly unknown, and there are no reliable biomarkers to predict the development of new-onset diabetes. In the present study, we demonstrate that a specific microRNA (miR-34a) contained in circulating extracellular vesicles released by endothelial cells reliably predicts the risk of developing new-onset diabetes in COVID-19. This association was independent of age, sex, body mass index (BMI), hypertension, dyslipidemia, smoking status, and D-dimer.
AB - Emerging evidence indicates that the relationship between coronavirus disease 2019 (COVID-19) and diabetes is 2-fold: 1) it is known that the presence of diabetes and other metabolic alterations poses a considerably high risk to develop a severe COVID-19; 2) patients who survived a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have an increased risk of developing new-onset diabetes. However, the mechanisms underlying this association are mostly unknown, and there are no reliable biomarkers to predict the development of new-onset diabetes. In the present study, we demonstrate that a specific microRNA (miR-34a) contained in circulating extracellular vesicles released by endothelial cells reliably predicts the risk of developing new-onset diabetes in COVID-19. This association was independent of age, sex, body mass index (BMI), hypertension, dyslipidemia, smoking status, and D-dimer.
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U2 - 10.1124/jpet.122.001253
DO - 10.1124/jpet.122.001253
M3 - Article
C2 - 38336381
AN - SCOPUS:85188029812
SN - 0022-3565
VL - 389
SP - 34
EP - 39
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 1
ER -
