Endoplasmic reticulum architecture: structures in flux

Nica Borgese, Maura Francolini, Erik Snapp

Research output: Contribution to journalReview articlepeer-review

172 Scopus citations


The endoplasmic reticulum (ER) is a dynamic pleiomorphic organelle containing continuous but distinct subdomains. The diversity of ER structures parallels its many functions, including secretory protein biogenesis, lipid synthesis, drug metabolism and Ca2+ signaling. Recent studies are revealing how elaborate ER structures arise in response to subtle changes in protein levels, dynamics, and interactions as well as in response to alterations in cytosolic ion concentrations. Subdomain formation appears to be governed by principles of self-organization. Once formed, ER subdomains remain malleable and can be rapidly transformed into alternative structures in response to altered conditions. The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles.

Original languageEnglish (US)
Pages (from-to)358-364
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number4
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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