Endocardially Derived Macrophages Are Essential for Valvular Remodeling

Ayako Shigeta, Vincent Huang, Jonathan Zuo, Rana Besada, Yasuhiro Nakashima, Yan Lu, Yichen Ding, Matteo Pellegrini, Rajan P. Kulkarni, Tzung Hsiai, Arjun Deb, Bin Zhou, Haruko Nakano, Atsushi Nakano

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.

Original languageEnglish (US)
Pages (from-to)617-630.e3
JournalDevelopmental cell
Issue number5
StatePublished - Mar 11 2019


  • cardiac tissue macrophage
  • cardiogenesis
  • congenital heart disease
  • hematopoiesis
  • hemogenic endocardium
  • multipotent cardiac progenitor cells
  • tissue macrophages
  • valve disease
  • valve remodeling
  • valvulogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology


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