Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically

Mario Alexander Penzo, José Luis Peña

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Here, we examined long-term synaptic plasticity in the avian auditory midbrain, a region involved in experience-dependent learning. We found that coactivation of N-methyl-D-aspartate receptors (NMDAR) and type 1 cannabinoid receptors (CB1R) induces long-term depression (LTD) at the synapse between the central shell and the external portion of the inferior colliculus of the chicken. Although endocannabinoids are commonly thought of as presynaptic modulators, recent reports have suggested that they can also modulate the postsynaptic site. In the avian midbrain, we found that LTD is mediated by both presynaptic and postsynaptic changes. The presynaptic mechanism consists of a decrease in neurotransmitter release, whereas a depression of NMDAR-mediated current takes place on the postsynaptic side. Both the presynaptic and the postsynaptic effects depend on CB1R activation. The reduction of postsynaptic NMDAR currents represents a novel role of endocannabinoids in synaptic modulation.

Original languageEnglish (US)
Pages (from-to)4131-4139
Number of pages9
JournalJournal of Neuroscience
Issue number13
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically'. Together they form a unique fingerprint.

Cite this