Emerging trends in G-quadruplex biology-role in epigenetic and evolutionary events

Aradhita Baral, Pankaj Kumar, Rajiv Pathak, Shantanu Chowdhury

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


G-quadruplex biology gained interest based on evidence supporting its widespread role as elements that can control or modulate gene regulation. This followed initial prediction based on computational analysis that found prevalence of quadruplex motifs in promoters of many bacterial and other organisms. In parallel, further evidence was found indicating the function of quadruplex motifs in replication, recombination and also DNA repair. In this review, we summarize recent findings that provide a new perspective by introducing quadruplex motifs in roles that support involvement during epigenetic events, in determining evolutionary selection and as possible determinants of quantitative expression traits (eQTL) across populations.

Original languageEnglish (US)
Pages (from-to)1568-1575
Number of pages8
JournalMolecular BioSystems
Issue number7
StatePublished - Jul 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology


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