TY - JOUR
T1 - Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
AU - Qureshi, Irfan A.
AU - Mehler, Mark F.
N1 - Funding Information:
The authors regret that space constraints have prevented the citation of many relevant and important references. M.F.M. is supported by grants from the US National Institutes of Health (NS071571, HD071593 and MH66290), as well as by the F.M. Kirby, Alpern Family, Mildred and Bernard H. Kayden and Roslyn and Leslie Goldstein Foundations.
PY - 2012/8
Y1 - 2012/8
N2 - Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.
AB - Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.
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U2 - 10.1038/nrn3234
DO - 10.1038/nrn3234
M3 - Review article
C2 - 22814587
AN - SCOPUS:84864126183
SN - 1471-003X
VL - 13
SP - 528
EP - 541
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 8
ER -