TY - JOUR
T1 - Emerging roles for macrophages in cardiac injury
T2 - Cytoprotection, repair, and regeneration
AU - Frangogiannis, Nikolaos G.
N1 - Publisher Copyright:
© 2015, American Society for Clinical Investigation. All rights reserved.
PY - 2015/8/3
Y1 - 2015/8/3
N2 - The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction through the recruitment of monocytes. Infarct macrophages exhibit high phenotypic diversity and respond to microenvironmental cues by altering their functional properties and secretory profile. In this issue of the JCI, de Couto and colleagues demonstrate that infiltrating macrophages can be primed to acquire a cardioprotective phenotype in ischemic heart and exert this proactive effect through activation of an antiapoptotic program in cardiomyocytes. This study supports the growing body of evidence that suggests that macrophage subpopulations can be modulated to mediate cytoprotective, reparative, and even regenerative functions in the infarcted heart. The cellular mechanisms and molecular signals driving these macrophage phenotypes are yet unknown; however, harnessing the remarkable potential of the macrophage in regulating cell survival and tissue regeneration may hold therapeutic promise for myocardial infarction.
AB - The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction through the recruitment of monocytes. Infarct macrophages exhibit high phenotypic diversity and respond to microenvironmental cues by altering their functional properties and secretory profile. In this issue of the JCI, de Couto and colleagues demonstrate that infiltrating macrophages can be primed to acquire a cardioprotective phenotype in ischemic heart and exert this proactive effect through activation of an antiapoptotic program in cardiomyocytes. This study supports the growing body of evidence that suggests that macrophage subpopulations can be modulated to mediate cytoprotective, reparative, and even regenerative functions in the infarcted heart. The cellular mechanisms and molecular signals driving these macrophage phenotypes are yet unknown; however, harnessing the remarkable potential of the macrophage in regulating cell survival and tissue regeneration may hold therapeutic promise for myocardial infarction.
UR - http://www.scopus.com/inward/record.url?scp=84939228160&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939228160&partnerID=8YFLogxK
U2 - 10.1172/JCI83191
DO - 10.1172/JCI83191
M3 - Comment/debate
C2 - 26214519
AN - SCOPUS:84939228160
SN - 0021-9738
VL - 125
SP - 2927
EP - 2930
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 8
ER -