TY - JOUR
T1 - Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease
AU - Indaram, A. V.K.
AU - Nandi, S.
AU - Weissman, S.
AU - Lam, S.
AU - Bailey, B.
AU - Blumstein, M.
AU - Greenberg, R.
AU - Bank, S.
PY - 2000/2
Y1 - 2000/2
N2 - Aim: To determine levels of cytokines in colonic mucosa of asymptomatic first degree relatives of Crohn's disease patients. Methods: Cytokines (Interleukin (IL) 1-Beta, IL-2, IL-6 and IL-8) were measured using ELISA in biopsy samples of normal looking colonic mucosa of first degree relatives of Crohn's disease patients (n = 9) and from normal controls (n = 10) with no family history of Crohn's disease. Results: Asymptomatic first degree relatives of patients with Crohn's disease had significantly higher levels of basal intestinal mucosal cytokines (IL-2, IL-6 and IL-8) than normal controls. Whether these increased cytokine levels serve as phenotypic markers for a genetic predisposition to developing Crohn's disease later on, or whether they indicate early (pre-clinical) damage has yet to be further defined. Conclusion: Asymptomatic first degree relatives of Crohn's disease patients have higher levels of cytokines in their normal-looking intestinal mucosa compared to normal controls. This supports the hypothesis that increased cytokines may be a cause or an early event in the inflammatory cascade of Crohn's disease and are not merely a result of the inflammatory process.
AB - Aim: To determine levels of cytokines in colonic mucosa of asymptomatic first degree relatives of Crohn's disease patients. Methods: Cytokines (Interleukin (IL) 1-Beta, IL-2, IL-6 and IL-8) were measured using ELISA in biopsy samples of normal looking colonic mucosa of first degree relatives of Crohn's disease patients (n = 9) and from normal controls (n = 10) with no family history of Crohn's disease. Results: Asymptomatic first degree relatives of patients with Crohn's disease had significantly higher levels of basal intestinal mucosal cytokines (IL-2, IL-6 and IL-8) than normal controls. Whether these increased cytokine levels serve as phenotypic markers for a genetic predisposition to developing Crohn's disease later on, or whether they indicate early (pre-clinical) damage has yet to be further defined. Conclusion: Asymptomatic first degree relatives of Crohn's disease patients have higher levels of cytokines in their normal-looking intestinal mucosa compared to normal controls. This supports the hypothesis that increased cytokines may be a cause or an early event in the inflammatory cascade of Crohn's disease and are not merely a result of the inflammatory process.
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U2 - 10.3748/wjg.v6.i1.49
DO - 10.3748/wjg.v6.i1.49
M3 - Article
AN - SCOPUS:0033951930
SN - 1007-9327
VL - 6
SP - 49
EP - 52
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 1
ER -