Electrophysiology of ventricular fibrillation and defibrillation

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Introduction: Sudden cardiac death remains a major public health problem in the United States. Despite extensive study and effective treatments for malignant ventricular arrhythmias more than a quarter of a million people die suddenly each year in this country. Sudden death accounts for more than half of all deaths related to cardiovascular disease, coronary artery disease is the most common pathological condition found in patients who die suddenly, and ventricular fibrillation is the most common immediate cause of death. In the last decade a decline in the incidence of out-ofhospital ventricular fibrillation and a measurable improvement in the long-term survival of patients who have been resuscitated have been documented in the most wellstudied communities. Despite these gains and perhaps because of the changing etiology of cardiac arrest, the overall survival of cardiac arrest victims has not changed in the past two decades.3 In communities with the most sophisticated emergency medical services, the maximal survival rate for out-of-hospital ventricular fibrillation is about 30%. Understanding the mechanism of ventricular fibrillation is critical to making a meaningful impact on the incidence of this arrhythmia and improving the survival of sudden death victims. Ventricular fibrillation was described by Ludwig and Hoffa in 1849 as an incoordinate heart action that produced a high metabolic rate of the myocardium but no useful contractions.6 The hemodynamic consequences of the disordered cardiac contraction and the fundamental electrophysiologic basis of ventricular fibrillation were understood by the turn of the century. Porter, in 1898, stated that the essential nature of fibrillatory contractions is the result of abnormalities in impulse conduction.

Original languageEnglish (US)
Title of host publicationCardiac Arrest
Subtitle of host publicationThe Science and Practice of Resuscitation Medicine
PublisherCambridge University Press
Number of pages27
ISBN (Electronic)9780511544828
ISBN (Print)05218470041, 9780521847001
StatePublished - Jan 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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