Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome

S. Roy; C. K. Datta; A. Hirano; N. R. Ghatak; H. M. Zimmerman

doi:10.1007/BF00684775

Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome

S. Roy, C. K. Datta, A. Hirano, N. R. Ghatak, H. M. Zimmerman

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Acta neuropathologica
Volume	29
Issue number	2
DOIs	https://doi.org/10.1007/BF00684775
State	Published - Jun 1974
Externally published	Yes

Keywords

Electron Microscopy
Neurofibrillary Tangles
Progressive Supranuclear Palsy
Steele-Richardson-Olszewski Syndrome

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

Access to Document

10.1007/BF00684775

Cite this

@article{36aa3dd546b64c5d9c7e774891301d08,

title = "Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome",

abstract = "The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 {\AA} in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.",

keywords = "Electron Microscopy, Neurofibrillary Tangles, Progressive Supranuclear Palsy, Steele-Richardson-Olszewski Syndrome",

author = "S. Roy and Datta, {C. K.} and A. Hirano and Ghatak, {N. R.} and Zimmerman, {H. M.}",

year = "1974",

month = jun,

doi = "10.1007/BF00684775",

language = "English (US)",

volume = "29",

pages = "175--179",

journal = "Acta neuropathologica",

issn = "0001-6322",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome

AU - Roy, S.

AU - Datta, C. K.

AU - Hirano, A.

AU - Ghatak, N. R.

AU - Zimmerman, H. M.

PY - 1974/6

Y1 - 1974/6

N2 - The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.

AB - The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.

KW - Electron Microscopy

KW - Neurofibrillary Tangles

KW - Progressive Supranuclear Palsy

KW - Steele-Richardson-Olszewski Syndrome

UR - http://www.scopus.com/inward/record.url?scp=0016351662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016351662&partnerID=8YFLogxK

U2 - 10.1007/BF00684775

DO - 10.1007/BF00684775

M3 - Article

C2 - 4446944

AN - SCOPUS:0016351662

SN - 0001-6322

VL - 29

SP - 175

EP - 179

JO - Acta neuropathologica

JF - Acta neuropathologica

IS - 2

ER -

Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this