Electron microscopic study of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome

S. Roy, C. K. Datta, A. Hirano, N. R. Ghatak, H. M. Zimmerman

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalActa neuropathologica
Issue number2
StatePublished - Jun 1974
Externally publishedYes


  • Electron Microscopy
  • Neurofibrillary Tangles
  • Progressive Supranuclear Palsy
  • Steele-Richardson-Olszewski Syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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