TY - JOUR
T1 - Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region
AU - Manickam, Pachiappan
AU - Guru, Siradanahalli C.
AU - Debelenko, Larisa V.
AU - Agarwal, Sunita K.
AU - Olufemi, Shodimu Emmanuel
AU - Weisemann, Jane M.
AU - Boguski, Mark S.
AU - Crabtree, Judy S.
AU - Wang, Yingping
AU - Roe, Bruce A.
AU - Lubensky, Irina A.
AU - Zhuang, Zhengping
AU - Rester, Mary Beth
AU - Burns, A. Lee
AU - Spiegel, Allen M.
AU - Marx, Stephen J.
AU - Liotta, Lance A.
AU - Emmert-Buck, Michael R.
AU - Collins, Francis S.
AU - Chandrasekharappa, Settara C.
N1 - Funding Information:
Acknowledgements We would like to thank Dr. Michael Poly-meropoulos for providing CEPH DNA samples. We are also thankful to Darryl Leja for preparing the illustration. We would also like to acknowledge a DOE graduate fellowship to J.S.C. and an NHGRI grant HG00 313 to B.A.R.
PY - 1997
Y1 - 1997
N2 - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high density clone contig-based, physical map generated for the MEN1 region.
AB - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high density clone contig-based, physical map generated for the MEN1 region.
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U2 - 10.1007/s004390050595
DO - 10.1007/s004390050595
M3 - Article
C2 - 9385379
AN - SCOPUS:0031438435
SN - 0340-6717
VL - 101
SP - 102
EP - 108
JO - Human Genetics
JF - Human Genetics
IS - 1
ER -