Abstract
To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-24 |
| Number of pages | 4 |
| Journal | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology |
| Volume | 17 |
| Issue number | 1 |
| State | Published - Feb 2001 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine