Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine

Serge Sevy; Serena Lynn Brown; Scott Wetzler; Moshe Kotler; Avi Molcho; Robert Plutchik; Herman M. van Praag

doi:10.1016/0165-1781(94)90051-5

Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine

Serge Sevy, Serena Lynn Brown, Scott Wetzler, Moshe Kotler, Avi Molcho, Robert Plutchik, Herman M. van Praag

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.

Original language	English (US)
Pages (from-to)	219-229
Number of pages	11
Journal	Psychiatry Research
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(94)90051-5
State	Published - Sep 1994

Keywords

Serotonin
cortisol
growth hormone
prolactin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(94)90051-5

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title = "Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine",

abstract = "The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.",

keywords = "Serotonin, cortisol, growth hormone, prolactin",

author = "Serge Sevy and Brown, {Serena Lynn} and Scott Wetzler and Moshe Kotler and Avi Molcho and Robert Plutchik and {van Praag}, {Herman M.}",

year = "1994",

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doi = "10.1016/0165-1781(94)90051-5",

language = "English (US)",

volume = "53",

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journal = "Psychiatry Research",

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AU - Sevy, Serge

AU - Brown, Serena Lynn

AU - Wetzler, Scott

AU - Kotler, Moshe

AU - Molcho, Avi

AU - Plutchik, Robert

AU - van Praag, Herman M.

PY - 1994/9

Y1 - 1994/9

N2 - The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.

AB - The effects of alprazolam, a triazolobenzodiazepine, on hormonal and behavioral responses induced by meta-chlorophenylpiperazine (MCPP), a serotonin receptor agonist, were investigated in 10 healthy men. Alprazolam (0.5 mg) or placebo was given 1 hour before MCPP (0.5 mg/kg) or placebo. Cortisol, prolactin, and growth hormone (GH) release, MCPP and alprazolam plasma levels, anxiety level, and panic symptoms were measured over 210 minutes. MCPP was found to increase cortisol, prolactin, GH, and anxiety levels. Alprazolam decreased cortisol and GH levels but had no effect on prolactin. When used in combination with MCPP, alprazolam blunted MCPP-induced cortisol and GH release, and it blocked the anxiogenic effects of MCPP.

KW - Serotonin

KW - cortisol

KW - growth hormone

KW - prolactin

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U2 - 10.1016/0165-1781(94)90051-5

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JF - Psychiatry Research

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ER -

Effects of alprazolam on increases in hormonal and anxiety levels induced by meta-chlorophenylpiperazine

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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