Effect of zafirlukast on cough reflex sensitivity in asthmatics

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33 Scopus citations


In patients with asthma, increased sensitivity of airway sensory nerves may be involved in producing bronchospasm and cough. To evaluate the effect of a leukotriene-modifying agent on cough reflex sensitivity, we measured the cough response to inhaled capsaicin before and after a 14-day course of therapy with zafirlukast, a cysteinyl leukotriene receptor antagonist, in a group of stable asthmatics. The concentration of capsaicin inducing two or more (C2) and five or more (C5) coughs was not altered by zafirlukast, even in those subjects demonstrating a significant change (increment or decrement) in forced expiratory volume in 1 sec (FEV1). These findings support previous evidence that cough and bronchoconstriction are modulated by distinct neural pathways.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalJournal of Asthma
Issue number3
StatePublished - 1999


  • Asthma
  • Capsaicin
  • Cough
  • Cough-variant asthma
  • Leukotriene receptor antagonists
  • Leukotrienes
  • Zafirlukast

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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