Effect of vitamin E on peroxidation and permeability of the peritoneum

K. Wieczorowska-Tobis, A. Brȩborowicz, J. Witowski, L. Martis, D. G. Oreopoulos

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Because of the evidence that peritoneal macrophages are activated during peritoneal dialysis, we hypothesised that the injury of the peritoneum is, at least in part, dependent on the intraperitoneal generation of free radicals. The aim of the study was to evaluate the effect of vitamin E on the peroxidation and permeability of the peritoneum during chronic peritoneal dialysis in rats. Supplementation of the intraperitoneally infused saline with vitamin E decreased the peroxidation of peritoneum estimated as the malondialdehyde (MDA) level in rats' omentum. However the permeability of the peritoneum to glucose and protein in vitamin E treated rats was increased. In in vitro study we have found that vitamin E is cytotoxic to human mesothelial cells (HMC) as measured by inhibition of their proliferation and this effect was irreversible. We conclude that vitamin E, despite its antioxidant effect, causes the changes of the peritoneum permeability which could decrease the effectiveness of peritoneal dialysis.

Original languageEnglish (US)
Pages (from-to)535-543
Number of pages9
JournalJournal of Physiology and Pharmacology
Issue number3
StatePublished - Sep 1996
Externally publishedYes


  • free radicals
  • mesothelial cells
  • peritoneal permeability
  • vitamin E

ASJC Scopus subject areas

  • Physiology
  • Pharmacology


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