TY - JOUR
T1 - Effect of type of alcoholic beverage on the risks of upper aerodigestive tract cancers in Brazil
AU - Schlecht, N. F.
AU - Pintos, J.
AU - Kowalski, L. P.
AU - Franco, E. L.
N1 - Funding Information:
We are indebted to the other participants in the Ludwig Institute for Cancer Research's Upper Respiratory and Digestive System Cancer Study Group: Benedito V. Oliveira, Erasto Gaertner Hospital, Curitiba; Maria P. Curado, Araujo Jorge Hospital, Goiaà nia; Antonio S. Fava, Heliopolis Hospital, SaÄ o Paulo, Brazil; Clinical Committee: Drs M. B. Carvalho, A. Rapoport, J. And-rade-Sobrinho, G. Ramos, J. L. Kanda, J. F. Gois, J. S. Chagas, and G. A. Teixeira; Pathology Committee: Drs H. Torloni, W. T. Vieira, L. A. Sampaio, and V. M. Cardoso; data acquisition and management: M. E. Silva, R. N. Pereira, N. Campos-Filho, L. Fanes, V. N. Souza, and M. S. Morais. N.F.S. is recipient of a Doctoral Scholarship and E.L.F. of a Distinguished Scientist Award, both from the Medical Research Council of Canada. Financial support was received from the Ludwig Institute for Cancer Research, and Cancer Research Society of Canada.
PY - 2001
Y1 - 2001
N2 - Objectives: We investigated the effects of alcohol consumption on the risk of cancers of the upper aerodigestive tract (UADT) in a hospital-based case-control study in Brazil. Methods: A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1578 non-cancer controls matched on age, gender, hospital area, and admission period provided information on alcohol drinking, smoking, and other characteristics via interview. Using logistic regression, we evaluated the relative risks (RR) of UADT cancer for different beverage types based on cumulative ethanol content exposure and frequency of consumption. Results: Relative to nondrinkers of any alcohol, risks of UADT cancers varied across sites both with increased exposure to ethanol and by alcohol type. RRs at equivalent levels of ethanol consumption were highest for cancers of the mouth for hard liquor (6.9 for > 100 kg lifetime consumption, 95% confidence interval (CI)= 2.8-17.1) and cachaça (4.5 for 101-500 kg, 95% CI = 2.2-9.0). Although RRs increased with frequency of drinks per week, when evaluated against higher proportional alcohol intake, reductions in risk were observed for beer and wine. Conclusion: Although methods of measurement can influence the interpretation of the carcinogenic nature of alcohols, increased RRs persisted with continued exposure for all types.
AB - Objectives: We investigated the effects of alcohol consumption on the risk of cancers of the upper aerodigestive tract (UADT) in a hospital-based case-control study in Brazil. Methods: A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1578 non-cancer controls matched on age, gender, hospital area, and admission period provided information on alcohol drinking, smoking, and other characteristics via interview. Using logistic regression, we evaluated the relative risks (RR) of UADT cancer for different beverage types based on cumulative ethanol content exposure and frequency of consumption. Results: Relative to nondrinkers of any alcohol, risks of UADT cancers varied across sites both with increased exposure to ethanol and by alcohol type. RRs at equivalent levels of ethanol consumption were highest for cancers of the mouth for hard liquor (6.9 for > 100 kg lifetime consumption, 95% confidence interval (CI)= 2.8-17.1) and cachaça (4.5 for 101-500 kg, 95% CI = 2.2-9.0). Although RRs increased with frequency of drinks per week, when evaluated against higher proportional alcohol intake, reductions in risk were observed for beer and wine. Conclusion: Although methods of measurement can influence the interpretation of the carcinogenic nature of alcohols, increased RRs persisted with continued exposure for all types.
KW - Alcohol drinking
KW - Case-control studies
KW - Epidemiologic methods
KW - Ethanol
KW - Head and neck neoplasias
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U2 - 10.1023/A:1011226520220
DO - 10.1023/A:1011226520220
M3 - Article
C2 - 11552705
AN - SCOPUS:0034877960
SN - 0957-5243
VL - 12
SP - 579
EP - 587
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 7
ER -