Effect of Met-enkephalin and opioid antagonists on rat macrophages

Jelena Radulovic, Mirjana Dimitrijević, Olgica Laban, Stanislava Stanojević, Tatjana Vasiljević, Vesna Kovačević-Jovanović, Branislav M. Marković

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.

Original languageEnglish (US)
Pages (from-to)1209-1213
Number of pages5
Issue number7
StatePublished - 1995
Externally publishedYes


  • AO rats
  • DA rats
  • HO release
  • Met-enkephalin
  • Opioid antagonists
  • Rat peritoneal macrophages

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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