Effect of Met-enkephalin and opioid antagonists on rat macrophages

Jelena Radulovic; Mirjana Dimitrijević; Olgica Laban; Stanislava Stanojević; Tatjana Vasiljević; Vesna Kovačević-Jovanović; Branislav M. Marković

doi:10.1016/0196-9781(95)02003-F

Effect of Met-enkephalin and opioid antagonists on rat macrophages

Jelena Radulovic, Mirjana Dimitrijević, Olgica Laban, Stanislava Stanojević, Tatjana Vasiljević, Vesna Kovačević-Jovanović, Branislav M. Marković

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H₂O₂ release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H₂O₂ production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H₂O₂ release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.

Original language	English (US)
Pages (from-to)	1209-1213
Number of pages	5
Journal	Peptides
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/0196-9781(95)02003-F
State	Published - 1995
Externally published	Yes

Keywords

AO rats
DA rats
HO release
Met-enkephalin
Opioid antagonists
Rat peritoneal macrophages

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(95)02003-F

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@article{7f6a0e0711a0434387ef778ff84def84,

title = "Effect of Met-enkephalin and opioid antagonists on rat macrophages",

abstract = "Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.",

keywords = "AO rats, DA rats, HO release, Met-enkephalin, Opioid antagonists, Rat peritoneal macrophages",

author = "Jelena Radulovic and Mirjana Dimitrijevi{\'c} and Olgica Laban and Stanislava Stanojevi{\'c} and Tatjana Vasiljevi{\'c} and Vesna Kova{\v c}evi{\'c}-Jovanovi{\'c} and Markovi{\'c}, {Branislav M.}",

note = "Funding Information: This work was supportedb y the Ministry of Science and Technology of the Republic of Serbia. We thank Zuzana Holubek for technical assistance.",

year = "1995",

doi = "10.1016/0196-9781(95)02003-F",

language = "English (US)",

volume = "16",

pages = "1209--1213",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Effect of Met-enkephalin and opioid antagonists on rat macrophages

AU - Radulovic, Jelena

AU - Dimitrijević, Mirjana

AU - Laban, Olgica

AU - Stanojević, Stanislava

AU - Vasiljević, Tatjana

AU - Kovačević-Jovanović, Vesna

AU - Marković, Branislav M.

N1 - Funding Information: This work was supportedb y the Ministry of Science and Technology of the Republic of Serbia. We thank Zuzana Holubek for technical assistance.

PY - 1995

Y1 - 1995

N2 - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.

AB - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.

KW - AO rats

KW - DA rats

KW - HO release

KW - Met-enkephalin

KW - Opioid antagonists

KW - Rat peritoneal macrophages

UR - http://www.scopus.com/inward/record.url?scp=0028867675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028867675&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(95)02003-F

DO - 10.1016/0196-9781(95)02003-F

M3 - Article

C2 - 8545240

AN - SCOPUS:0028867675

SN - 0196-9781

VL - 16

SP - 1209

EP - 1213

JO - Peptides

JF - Peptides

IS - 7

ER -

Effect of Met-enkephalin and opioid antagonists on rat macrophages

Abstract

Keywords

ASJC Scopus subject areas

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