Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

A. Cruz, I. Tasset, L. M. Ramírez, A. Arjona, J. Segura, I. Túnez, P. Montilla, J. Muntané, Francisco J. Padillo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalRevista Espanola de Enfermedades Digestivas
Issue number7
StatePublished - Jul 2009
Externally publishedYes


  • Antioxidants
  • Cardiac dysfunction
  • Cholestasis
  • Melatonin
  • Oxidative stress

ASJC Scopus subject areas

  • Gastroenterology


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