@article{b87bd88ae52e4382811223175801cc52,
title = "Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study",
abstract = "We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women. The effects of antiretroviral therapy (ART) on Lp(a) levels in relation to apo(a) size polymorphism remain unclear. ART effects on allele-specific apo(a) level (ASL), an Lp(a) level associated with individual apo(a) alleles within each allele-pair, were determined in 126 HIV-seropositive women. ART effects were tested by a mixed-effects model across pre-ART and post-ART first and third visits. Data from 120 HIV-seronegative women were used. The mean age was 38 years; most were African-American (∼70%). Pre-ART ASLs associated with the larger (4.6 mg/dl vs. 8.0 mg/dl, P = 0.024) or smaller (13 mg/dl vs. 19 mg/dl, P = 0.041) apo(a) sizes were lower in the HIV-seropositive versus HIV-seronegative group, as was the prevalence of a high Lp(a) level (P = 0.013). Post-ART ASL and prevalence of high Lp(a) or apo(a) sizes and frequency of small size apo(a) (≤22 kringles) did not differ between the two groups. ART increased Lp(a) level (from 18 to 24 mg/dl, P < 0.0001) and both ASLs (P < 0.001). In conclusion, regardless of genetic control, Lp(a) can be modulated by HIV and its treatment. ART initiation abrogates HIV-induced suppression of Lp(a) levels and ASLs, contributing to promote CVD risk in HIV-seropositive individuals.",
keywords = "Apolipoprotein (a) sizes, Apolipoproteins, Biomarkers, Clinical studies, Drug therapy, Human immunodeficiency virus treatment, Lipoprotein (a), Lipoproteins, Longitudinal design, Molecular biology/genetics, Prospective cohort",
author = "Byambaa Enkhmaa and Erdembileg Anuurad and Wei Zhang and Li, {Chin Shang} and Robert Kaplan and Jason Lazar and Dan Merenstein and Roksana Karim and Brad Aouizerat and Mardge Cohen and Kenneth Butler and Savita Pahwa and Igho Ofotokun and Adimora, {Adaora A.} and Elizabeth Golub and Lars Berglund",
note = "Funding Information: The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute of Mental Health (NIMH). Targeted supplemental funding for specific projects is also provided by the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute on Deafness and other Communication Disorders (NIDCD), and the National Institutes of Health (NIH) Office of Research on Women{\textquoteright}s Health. WIHS data collection is also supported by UL1-TR000004 (UCSF CTSA) and UL1-TR000454 (Atlanta CTSA). The study was also supported by the NIH-supported UCD Clinical and Translational Science Center base operating grant (TR001860), NIH K12 Building Interdisciplinary Research Career in Women{\textquoteright}s Health Program (NIH2K12HD051958) and grants R01HL126543, R01HL132794, R01HL083760, and R01HL095140 to R.K. Data in this work were collected by the Women{\textquoteright}s Interagency HIV Study (WIHS). WIHS (Principal Investigators): UAB-MS WIHS (Michael Saag, Mirjam-Colette Kempf, and Deborah Konkle-Parker), U01-AI-103401; Atlanta WIHS (Ighovw-erha Ofotokun and Gina Wingood), U01-AI-103408; Bronx WIHS (Kathryn Anastos), U01-AI-035004; Brooklyn WIHS (Howard Minkoff and Deborah Gustafson), U01-AI-031834; Chicago WIHS (Mardge Cohen and Audrey French), U01-AI-034993; Metropolitan Washington WIHS (Seble Kassaye), U01-AI-034994; Miami WIHS (Margaret Fischl and Lisa Metsch), U01-AI-103397; UNC WIHS (Adaora Adimora), U01-AI-103390; Connie Wofsy Women{\textquoteright}s HIV Study, Northern California (Ruth Greenblatt, Bradley Aouizerat, and Phyllis Tien), U01-AI-034989; WIHS Data Management and Analysis Center (Stephen Gange and Elizabeth Golub), U01-AI-042590; Southern California WIHS (Joel Milam), U01-HD-032632 (WIHS I–WIHS IV). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health. Manuscript received 20 February 2018 and in revised form 8 June 2018. Published, JLR Papers in Press, July 16, 2018 DOI https://doi.org/10.1194/jlr.P084517 Publisher Copyright: Copyright {\textcopyright} 2018 Enkhmaa et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.",
year = "2018",
doi = "10.1194/jlr.P084517",
language = "English (US)",
volume = "59",
pages = "1967--1976",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "10",
}
