Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun, Lin Xie, Xiaoou Mao, Justin Hill, David A. Greenberg, Kunlin Jin

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalRestorative Neurology and Neuroscience
Issue number6
StatePublished - 2012
Externally publishedYes


  • Stroke
  • ischemia
  • rat
  • recovery

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology


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