Ectopic Prolactin Secretion from a Uterine Leiomyoma

Saachi Sachdev, Maria Carolina Reyes, Peter J. Snyder

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ectopic hormone production is well recognized, but ectopic production of prolactin has been reported infrequently. We report here the case of a 47-year-old woman who had hyperprolactinemia (213-224 ng/mL) causing galactorrhea and hypogonadism. Cabergoline treatment, 1.0 mg twice a week, did not lower the prolactin level at all, but excision of a large uterine leiomyoma corrected the hyperprolactinemia and the hypogonadism. The excised leiomyoma tissue exhibited immunostaining for prolactin, confirming by this method for the first time that a uterine leiomyoma was the cause of hyperprolactinemia. This case illustrates the need to consider an ectopic source of prolactin in a patient who has hyperprolactinemia that is not associated with a large sellar mass and is completely resistant to cabergoline.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of the Endocrine Society
Issue number4
StatePublished - 2020
Externally publishedYes


  • Dopamine agonist resistant
  • Ectopic prolactin
  • Leiomyoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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