Early T-cell precursor leukemia/lymphoma in adults and children

Ashleigh Allen; Anthony Sireci; Adrianna Colovai; Kerice Pinkney; Maria Sulis; Govind Bhagat; Bachir Alobeid

doi:10.1016/j.leukres.2013.06.010

Early T-cell precursor leukemia/lymphoma in adults and children

Ashleigh Allen, Anthony Sireci, Adrianna Colovai, Kerice Pinkney, Maria Sulis, Govind Bhagat, Bachir Alobeid

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p= 0.127, and children, HR = 11.63, p= 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.

Original language	English (US)
Pages (from-to)	1027-1034
Number of pages	8
Journal	Leukemia Research
Volume	37
Issue number	9
DOIs	https://doi.org/10.1016/j.leukres.2013.06.010
State	Published - Sep 2013
Externally published	Yes

Keywords

ALL
Acute leukemia
Adults
Children
Early T-cell precursors
Leukemia
Lymphoblastic
Lymphoma
Prognosis

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2013.06.010

Cite this

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title = "Early T-cell precursor leukemia/lymphoma in adults and children",

abstract = "Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p= 0.127, and children, HR = 11.63, p= 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.",

keywords = "ALL, Acute leukemia, Adults, Children, Early T-cell precursors, Leukemia, Lymphoblastic, Lymphoma, Prognosis",

author = "Ashleigh Allen and Anthony Sireci and Adrianna Colovai and Kerice Pinkney and Maria Sulis and Govind Bhagat and Bachir Alobeid",

year = "2013",

month = sep,

doi = "10.1016/j.leukres.2013.06.010",

language = "English (US)",

volume = "37",

pages = "1027--1034",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Early T-cell precursor leukemia/lymphoma in adults and children

AU - Allen, Ashleigh

AU - Sireci, Anthony

AU - Colovai, Adrianna

AU - Pinkney, Kerice

AU - Sulis, Maria

AU - Bhagat, Govind

AU - Alobeid, Bachir

PY - 2013/9

Y1 - 2013/9

N2 - Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p= 0.127, and children, HR = 11.63, p= 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.

AB - Early T-cell precursor-ALL (ETP-ALL) is a subtype of T-ALL with a poor prognosis in children. We analyzed ETP-ALL compared to conventional T-ALL/LBL in both adults and children to determine any differences in clinical outcomes, based on the following parameters: induction failure, relapse, and survival. Patients with ETP-ALL have a higher risk of relapse, especially in children (in all patients, HR = 4.08, p= 0.127, and children, HR = 11.63, p= 0.025). ETP-ALL seems to have an increased risk of adverse outcomes, particularly in children. Larger studies are needed to better determine the prognosis of this subtype of T-ALL.

KW - ALL

KW - Acute leukemia

KW - Adults

KW - Children

KW - Early T-cell precursors

KW - Leukemia

KW - Lymphoblastic

KW - Lymphoma

KW - Prognosis

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U2 - 10.1016/j.leukres.2013.06.010

DO - 10.1016/j.leukres.2013.06.010

M3 - Article

C2 - 23827350

AN - SCOPUS:84880931588

SN - 0145-2126

VL - 37

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EP - 1034

JO - Leukemia Research

JF - Leukemia Research

IS - 9

ER -

Early T-cell precursor leukemia/lymphoma in adults and children

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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