Early-life course socioeconomic factors and chronic kidney disease

The CKD Life Course Group

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Kidney failure or ESRD affects approximately 650,000 Americans, whereas the number with earlier stages of CKD is much higher. Although CKD and ESRD are usually associated with adulthood, it is likely that the initial stages of CKD begin early in life. Many of these pathways are associated with low birth weight and disadvantaged socioeconomic status (SES) in childhood, translating childhood risk into later-life CKD and kidney failure. Social factors are thought to be fundamental causes of disease. Although the relationship between adult SES and CKD has been well established, the role of early childhood SES for CKD risk remains obscure. This review provides a rationale for examining the association between early-life SES and CKD. By collecting data on early-life SES and CKD, the interaction with other periods in the life course could also be studied, allowing for examination of whether SES trajectories (eg, poverty followed by affluence) or cumulative burden (eg, poverty at multiple time points) are more relevant to lifetime CKD risk.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalAdvances in Chronic Kidney Disease
Issue number1
StatePublished - Jan 1 2015


  • Chronic kidney disease
  • Epidemiology
  • Health disparities
  • Life course
  • Socioeconomic status

ASJC Scopus subject areas

  • Nephrology


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