TY - JOUR
T1 - Early forebrain wiring
T2 - Genetic dissection using conditional Celsr3 mutant mice
AU - Zhou, Libing
AU - Bar, Isabelle
AU - Achouri, Younès
AU - Campbell, Kenneth
AU - De Backer, Olivier
AU - Hebert, Jean M.
AU - Jones, Kevin
AU - Kessaris, Nicoletta
AU - De Rouvroit, Catherine Lambert
AU - O'Leary, Dennis
AU - Richardson, William D.
AU - Goffinet, Andre M.
AU - Tissir, Fadel
PY - 2008/5/16
Y1 - 2008/5/16
N2 - Development of axonal tracts requires interactions between growth cones and the environment. Tracts such as the anterior commissure and internal capsule are defective in mice with null mutation of Celsr3. We generated a conditional Celsr3 allele, allowing regional inactivation. Inactivation in telencephalon, ventral forebrain, or cortex demonstrated essential roles for Celsr3 in neurons that project axons to the anterior commissure and subcerebral targets, as well as in cells that guide axons through the internal capsule. When Celsr3 was inactivated in cortex, subcerebral projections failed to grow, yet corticothalamic axons developed normally, indicating that besides guidepost cells, additional Celsr3-independent cues can assist their progression. These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals.
AB - Development of axonal tracts requires interactions between growth cones and the environment. Tracts such as the anterior commissure and internal capsule are defective in mice with null mutation of Celsr3. We generated a conditional Celsr3 allele, allowing regional inactivation. Inactivation in telencephalon, ventral forebrain, or cortex demonstrated essential roles for Celsr3 in neurons that project axons to the anterior commissure and subcerebral targets, as well as in cells that guide axons through the internal capsule. When Celsr3 was inactivated in cortex, subcerebral projections failed to grow, yet corticothalamic axons developed normally, indicating that besides guidepost cells, additional Celsr3-independent cues can assist their progression. These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals.
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U2 - 10.1126/science.1155244
DO - 10.1126/science.1155244
M3 - Article
C2 - 18487195
AN - SCOPUS:44249105664
SN - 0036-8075
VL - 320
SP - 946
EP - 949
JO - Science
JF - Science
IS - 5878
ER -